GB102 FILETYPE PDF

Kazrall Kindly post your details and he will contact you. Phone is in incorrect mode and not respond ok after send loader. What is fastboot added WIPE? Some Friend saying coolsand reading and writing Speed is little slow.

Author:Mazunos Vorn
Country:Guadeloupe
Language:English (Spanish)
Genre:Travel
Published (Last):13 October 2010
Pages:260
PDF File Size:1.86 Mb
ePub File Size:16.79 Mb
ISBN:648-5-51840-860-4
Downloads:27003
Price:Free* [*Free Regsitration Required]
Uploader:Zukazahn



The company is working with an approved cancer treatment, Sutent, which has demonstrated the ability to restore vision in patients who also suffer from Wet AMD. The company also is working on an annual injection. Animal studies showed no evidence of inflammation or toxicity.

The company must complete one more animal study before filing for an IND. The company is on track to file an IND in Participant: Jeffrey Cleland, PhD Jeff has 20 years of industry experience in research and development, including more than a decade at Genentech, Inc.

We think we have a potential transformative therapy where we can dose potentially twice per year with a drug that targets both the VEGF receptor and the PDGF receptor. We think this could have a significant advantage over the current therapies that are in the clinic, not only around reducing the treatment burden, but also targeting two different mechanisms that are somewhat validated.

The drug that we selected going forward is actually sunitinib. Interestingly enough, when you give Sutent, which is the approved form of sunitinib, orally to cancer patients, it gets into the ocular tissues and into the uveal tract in the eye at higher levels than we can treat already with patients with our drug.

And our Chief Medical Officer found a recent case study where he showed that there was a patient that was treated with renal cell carcinoma that had wet AMD that was refractory to anti-VEGF, and that patient actually responded to Sutent therapy and had an improvement in visual acuity.

Of course, we can inject Sutent into the eye because of the short half-life as was mentioned in the previous presentation. So how the technology works is we actually encapsulate the drug into PLJ microparticles. In terms of the toxicokinetic profile, this is a demonstration on the top curve is in orange is the RPE choroid.

You can see very, very high levels of sunitinib out to beyond 6 months. So this product could be at least 6 months, maybe 9-months release over the time course.

And in the blue is the retina, and in the black is the vitreous. Only a couple points detected in the red there. From a safety perspective, no inflammation, no toxicity out to 6 months. Now in terms of efficacy, obviously great half-life. What does it do in vivo in terms of efficacy? And this is a rabbit CNV model. And here what we show is that we give a single injection and we wait 10 weeks. So we give very low doses. Twenty-fold lower is the top dose of what I showed you in the TK slide.

We waited then after that dose for ten weeks. We did the laser in the rabbits, and then we looked for CNV area formation three weeks later. And you can see on the panel on the bottom left corner that in each case, our drug performed significantly better than aflibercept, even though it was given ten weeks before the laser treatment.

And this data will all be presented in a poster at AAO. So in conclusion, we believe we have potentially one of the best in class opportunities here to treat twice a year dosing in patients with wet AMD, and our glaucoma program is about one year behind that, so we hope to be able to share an update around that time.

ANTENNA ENGINEERING HANDBOOK VOLAKIS PDF

GB102 FILETYPE PDF

Bataxe USB not have power to keep phone. Go to Mtk tab Select Built-in-Boot v7. Restart the phone into Download Mode. About Huawei U Series unlock 1.

AUFBAUANLEITUNG PAVILLON 3X3 PDF

The company is working with an approved cancer treatment, Sutent, which has demonstrated the ability to restore vision in patients who also suffer from Wet AMD. The company also is working on an annual injection. Animal studies showed no evidence of inflammation or toxicity. The company must complete one more animal study before filing for an IND. The company is on track to file an IND in

34 PROYECTOS DE ELECTRNICA MODERNA CEKIT PDF

APK installer directly from volcano without any additional software or tool. What is Compromised box? Contact me for Confirmation. Also keep in mind that downgrading the firmware version can create problems.

Related Articles